Role of C-Reactive Protein in Atherogenesis
نویسندگان
چکیده
منابع مشابه
C-reactive protein in the arterial intima: role of C-reactive protein receptor-dependent monocyte recruitment in atherogenesis.
Infiltration of monocytes into the arterial wall is an early cellular event in atherogenesis. Recent evidence shows that C-reactive protein (CRP) is deposited in the arterial intima at sites of atherogenesis. In this study, we demonstrate that CRP deposition precedes the appearance of monocytes in early atherosclerotic lesions. CRP is chemotactic for freshly isolated human blood monocytes. A sp...
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The role of C-reactive protein (CRP) in atherosclerosis is controversially discussed. Whereas initial experimental studies suggested a pathogenic role for CRP in atherogenesis, more recent genetic data from Mendelian randomization trials failed to provide evidence for a causative role of CRP in cardiovascular disease. Also, experimental results from laboratories all over the world were indeed c...
متن کاملRole of C-reactive protein in atherogenesis: can the apolipoprotein E knockout mouse provide the answer?
OBJECTIVE Human C-reactive protein (CRP) was reported to accelerate atherosclerotic lesion development in male but not in female apolipoprotein E (apoE) knockout mice. Here, mice expressing rabbit CRP (rbCRP) were crossbred onto apoE knockout animals, and the effect on atherogenesis was studied. METHODS AND RESULTS Hemolytic complement activity could not be detected in apoE knockout mice. Fur...
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Black, David Samols, Michael Torzewski, Karl J. Lackner, Matthias Husmann, Maria Blettner Kurt Reifenberg, Hans-Anton Lehr, Daniela Baskal, Elena Wiese, Stephan C. Schaefer, Steven Provide the Answer? Role of C-Reactive Protein in Atherogenesis : Can the Apolipoprotein E Knockout Mouse Print ISSN: 1079-5642. Online ISSN: 1524-4636 Copyright © 2005 American Heart Association, Inc. All rights res...
متن کاملC-REACTIVE PROTEIN RESPONSE IN ANGINA PECTORIS
C-reactive protein (CRP) response was studied in 44 patients with acute angina pectoris admitted to the coronary care unit. 71 % of patients with acute myocardial infarction (MI)had positive CRP test while 73% of patients presumed to have unstable angina pectoris had negative CRP test. This test can be helpful in differentiating between acute MI and unstable angina pectoris.
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2005
ISSN: 1079-5642,1524-4636
DOI: 10.1161/01.atv.0000171983.95612.90